The breasts are two prominences located on the upper ventral region of the torso among humans and other primates. Both sexes develop breasts from the same embryological tissues. The relative size and development of the breasts is a major secondary sex distinction between females and males. There is also considerable variation in size between individuals. Female humans are the only mammals which permanently develop breasts at puberty; all other mammals develop their mammary tissue during the latter period of pregnancy; at puberty, estrogens, in conjunction with growth hormone, cause permanent breast growth.